Olomoucine II

SKU: orb1694393

Description

Olomoucine II is a selective cyclin-dependent kinase inhibitor with potent antiviral and anticancer properties. It suppresses cancer cell proliferation and synergizes with chemotherapeutics like daunorubicin, while also inhibiting replication of multiple viruses including HSV-1, CMV, and adenovirus.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 500735-47-7
• MW: 370.45
• Purity: 99.94% (May vary between batches)
• Formula: C₁₉H₂₆N₆O₂
• SMILES: C(C)(C)N1C=2C(=C(NCC3=C(O)C=CC=C3)N=C(N[C@H](CC)CO)N2)N=C1
• Target: ERK,P-gp,CDK
• Solubility: Methanol:Soluble;DMSO:Soluble

Bioactivity

• Target IC50:
  CDK7/cyclin H:0.45 μM|CDK2/cyclinE:0.1 μM|Cdk1/cyclin B:7.6 μM|CDK9-CyclinT:0.06 μM|CDK4/cyclinD1:19.8 μM
• In Vitro:
  Olomoucine II acts for 72 hours to inhibit the proliferation of various cells, with IC₅₀ values for HOS, T98G, HBL100, BT474, MCF-7, HT-29, CCRF-CEM, BV173, and HL60 cells being 9.3, 9.2, 10.5, 13.6, 5.0, 10.8, 5.3, 2.7, and 16.3 μM, respectively .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Olomoucine II

Compound Identifiers

PubChem CID

5494414