Olmesartan

SKU: orb1226259

Description

An angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. Hypertension Discontinued(In Vitro):Olmesartan (0.7-5 mM; 24, 48 and 72 h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode.(In Vivo):Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species.

Key Properties

• CAS Number: 144689-24-7
• MW: 446.5016
• Purity: >98% (HPLC)
• Formula: C₂₄H₂₆N₆O₃
• SMILES: O=C(C1=C(C(C)(O)C)N=C(CCC)N1CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O
• Target: Angiotensin Receptor
• Solubility: DMSO: ≥ 55 mg/mL

Bioactivity

• In Vivo:
  Repeated dosing of olmesartan (1 mg/kg, 2 mg/kg, p.o.) dose-dependently decreases mean arterial blood pressure (MAP) in SHR without significant influence on body weight and food intake during 10 weeks. Olmesartan (5 mg/kg/d, p.o.) and Hyd treatments lower systolic blood pressure to the same degree in mice. Olmesartan treatment inhibits cardiac hypertrophy, evaluated by echocardiography, heart weight, cross-sectional area of cardiomyocytes, and gene expression. Olmesartan treatment reverses decreased gene expressions of ACE2 and Mas receptor of Ren-Tg mice and inhibits enhanced NADPH oxidase (Nox)4 expression and reactive oxygen species.
• In Vitro:
  Olmesartan (0.7-5 mM; 24, 48 and 72 h) inhibits the growth of HeLa cells as a concentration- and time-dependent mode. Cell Viability Assay Cell line: Human cervical cancer cell line (HeLa). Concentration: 0.7-5 mM Incubation time: 24, 48 and 72 h. Result: IC50s against HeLa cell line are 4.685 and 1.651 mM for 48 and 72 h, respectively.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

RNH 6270 | CS 088

Quick Database Links

Gene Symbol

Angiotensin Receptor