Oleuropein

SKU: orb1300348

Description

Oleuropein is a secoiridoid polyphenol antioxidant derived from olive leaves. It is widely used in research on oxidative stress, inflammation, and metabolic syndromes, with applications in both in vitro assays and in vivo model studies.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 32619-42-4
• MW: 540.51
• Purity: 99.95% (May vary between batches)
• Formula: C₂₅H₃₂O₁₃
• SMILES: COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)\C(=C\C)[C@@H]1CC(=O)OCCc1ccc(O)c(O)c1
• Target: ROS,Aromatase,Apoptosis,PPAR,Cytochromes P450
• Solubility: H2O:92 mg/mL (170.21 mM);DMSO:50 mg/mL (92.51 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.7 mM);Ethanol:93 mg/mL (172.06 mM)

Bioactivity

• In Vivo:
  In swiss albino mice that spontaneously develop soft tissue sarcomas, Oleuropein (i.p. or p.o.) completely regresses tumors. In rats, Oleuropein (40 mg/kg, p.o.) protects from cardiac remodeling process after isoproterenol-induced myocardial infarction through inhibiting angiotensin-converting enzyme activity.
• In Vitro:
  In both J774A.1 cells and primary mouse macrophages, Oleuropein increases LPS-induced NO production. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. In TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells, Oleuropein inhibits cell proliferation and migration.

Storage & Handling

• Storage: store at low temperature,store under nitrogen,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

breast, Apoptosis, anti-atherogenic, antioxidant, anti-inflammatory, Aromatase, cancer, inhibit, oil, Oleuropein, olive, leaves, Inhibitor, Peroxisome proliferator-activated receptors, PPARγ, PPAR, ROS

Compound Identifiers

PubChem CID

5281544