Oleoylethanolamide

SKU: orb1309303

Description

Oleoylethanolamide is a potent endogenous ligand for the PPAR-α receptor. It is widely used in metabolic and appetite regulation research, serving as a key tool for in vitro and in vivo studies of lipid sensing and energy homeostasis.

Research Area

Metabolism Research, Molecular Biology

Key Properties

• CAS Number: 111-58-0
• MW: 325.53
• Purity: 99.98% (May vary between batches)
• Formula: C₂₀H₃₉NO₂
• SMILES: CCCCCCCC\C=C/CCCCCCCC(=O)NCCO
• Target: PPAR,Endogenous Metabolite
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.14 mM);DMSO:250 mg/mL (767.98 mM);H2O:< 0.1 mg/mL (insoluble)

Bioactivity

• In Vivo:
  Treatment with OEA (5 mg/kg/day, intraperitoneal injection, i.p.) significantly attenuated the progress of liver fibrosis in both two experimental animal models by blocking the activation of hepatic stellate cells (HSCs). Gene expression analysis of hepatic tissues indicated that OEA inhibited the expression of α-smooth muscle action (α-SMA) and collagen matrix, fibrosis markers, and genes involved in inflammation and extracellular matrix remodeling.
• In Vitro:
  In vitro studies showed that OEA inhibited transforming growth factor β1-stimulated HSCs activation through suppressing Smad2/3 phosphorylation, α-SMA expression and myofibroblast transformation.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, Endogenous Metabolite, Oleamide MEA, Oleoylethanolamide, Oleic acid monoethanolamide, N-Oleoylethanolamide, Human Endogenous Metabolite, PPAR, PPARα

Compound Identifiers

PubChem CID

5283454