Olanzapine

SKU: orb1308151

Description

Olanzapine (LY170053) is an atypical antipsychotic employed in schizophrenia and bipolar disorder research. It is widely used in both in vitro receptor binding assays and in vivo behavioral models to study its mechanisms and therapeutic effects.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 132539-06-1
• MW: 312.43
• Purity: 99.86%
• Formula: C₁₇H₂₀N₄S
• SMILES: CN1CCN(CC1)C1=NC2=C(NC3=C1C=C(C)S3)C=CC=C2
• Target: Autophagy,5-HT Receptor,Adrenergic Receptor,Mitophagy,Apoptosis,Dopamine Receptor,AChR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16 mM);DMSO:240 mg/mL (768.17 mM)

Bioactivity

• Target IC50:
  5-HT2A receptor:4 nM (Ki)|Muscarinic M1-5 Receptor:1.9-25 nM (Ki)|5-HT1 receptor:7 nM (Ki)|5-HT6 receptor:5 nM (Ki)|α1-adrenoceptor:19 nM (Ki)|5-HT2C receptor:11 nM (Ki)|5-HT3 receptor:57 nM (Ki)
• In Vivo:
  Olanzapine interacts with several key receptors associated with schizophrenia, demonstrating nanomolar affinity for dopamine, serotonin, alpha-1 adrenergic, and cholinergic receptors. Specifically, Olanzapine selectively targets striatal dopamine in the limbic and cortical regions of the brain, exhibiting no selectivity towards dopamine receptor subtypes.
• In Vitro:
  Olanzapine is a potent antagonist of DA and 5-HT receptors, which elevates the extracellular levels of DA metabolites, such as DOPAC, and the DA metabolite 3-methoxytyramine, in the prefrontal cortex, nucleus accumbens, and striatum of rats. Subcutaneous injections of Olanzapine (0.5-10 mg/kg) increase the levels of dopamine (DA) and norepinephrine (NE) in these regions in a dose-dependent manner. Additionally, Olanzapine significantly inhibits insulin, leading to the onset of obesity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

cell, Beta Receptor, DopamineReceptor, Dopamine Receptor, Dopamine, damage, antipsychotic, anticholinergic, Apoptosis, Autophagy, 5-HT, 5HT Receptor, 5HTReceptor, 5-hydroxytryptamine Receptor, AdrenergicReceptor, Adrenergic Receptor, 5-HT Receptor, 5-HT2, mAChR, LY 170053, LY170053, LY-170053, Mitochondrial Autophagy, mitochondrial, Mitophagy, Olanzapine, neuronal, Inhibitor, inhibit, Muscarinic acetylcholine receptor, HT, SH-SY5Y, Serotonin Receptor

Compound Identifiers

PubChem CID

135398745