Okadaic acid

SKU: orb1706881

Description

Okadaic acid is a potent marine toxin and selective protein phosphatase inhibitor that increases cellular protein phosphorylation. It is widely used in research to model diseases like Alzheimer's and cancer, both in vitro and in vivo, by inducing tau phosphorylation and acting as a tumor promoter.

Research Area

Cell Biology

Key Properties

• CAS Number: 78111-17-8
• MW: 805.00
• Purity: >98%
• Formula: C₄₄H₆₈O₁₃
• SMILES: O[C@H]1[C@@]2(O[C@]([C@@H](/C=C/[C@@H]3O[C@]4(CC3)O[C@@]5([C@@](CC4)(O[C@]([C@H](C[C@H](C)[C@]6(O[C@]7(CC[C@H]6C)CCCCO7)[H])O)(C(=C)[C@H]5O)[H])[H])[H])C)(CC(C)=C2)[H])O[C@H](C[C@@](C(O)=O)(C)O)CC1
• Target: Phosphatase
• Solubility: Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml).

Bioactivity

• Target IC50:
  PP2:0.5 nM|PP7:>1000 nM|PP2A:0.1-0.3 nM|PP5:3.5 nM|PP1:10-15 nM|PP1:15-50 nM|PP2B:~4000 nM|PP3:4 nM|PP3:3.7-4 nM|PP4:0.1 nM
• In Vivo:
  Okadaic Acid (100 μg; icv; single dose) can be used in male Wistar rats (250-300 g) to establish an Alzheimer's disease model.
• In Vitro:
  Okadaic acid, at concentrations ranging from 0 to 100 nM and after treatment periods of 24 or 48 hours, is capable of inhibiting the proliferation of AGS, MNK-45, and Caco 2 cells.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 677083

Compound Identifiers

PubChem CID

446512