OICR-0547

SKU: orb1708989

Description

OICR-0547 is an inactive analog of the WDR5-MLL interaction inhibitor OICR-9429, serving as a critical negative control in biochemical and cellular assays. This compound is utilized in epigenetics and cancer research to validate the on-target effects of WDR5 inhibition in studies of mixed lineage leukemia and other malignancies.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1801873-49-3
• MW: 542.55
• Formula: C₂₈H₂₉F₃N₄O₄
• SMILES: O=C1C=C(C(=CN1)C(=O)NC2=CC(=CC=C2N3CCOCC3)C=4C=CC=C(C4)CN5CCOCC5)C(F)(F)F
• Target: Others,JAK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (7.37 mM);DMSO:180 mg/mL (331.77 mM)

Bioactivity

• In Vivo:
  OICR-0547 (3 mg/kg, intravenous injection) and (30 mg/kg, intraperitoneal injection) can be used as a negative control model in NOD-SCID mice.
• In Vitro:
  OICR-0547 (0.1-100 μM) was used to treat K562 cells and Cebpap30/p30 cells. OICR-0547 had no effect on the viability of either cell line.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

OICR 0547, OICR0547, OICR-0547

Compound Identifiers

PubChem CID

91801179