Oglufanide

SKU: orb1220502

Description

Oglufanide is a naturally occurring thymic immunomodulatorand inhibits vascular endothelial growth factor (VEGF).

Key Properties

• CAS Number: 38101-59-6
• MW: 333.34
• Purity: >98% (HPLC)
• Formula: C₁₆H₁₉N₃O₅
• SMILES: N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
• Target: VEGFR
• Solubility: DMSO:15.5 mg/mL (46.50 mM)

Bioactivity

• In Vivo:
  Animal model: C57BL/6 immune competent mice, Lewis lung carcinoma (LLC) xenograft; Balb/C athymic mice, M21 human melanoma xenograft. Dosage: 1, 10, 50 and 100 mg/kg/day. Administration: Subcutaneous injection, 10 days. Result: Resulted in a dose-dependent inhibition of LLC tumor growth in syngeneic immune competent mice and showed a dose-dependent decrease in tumor volumes of xenografts in Balb/C athymic mice implanted with M21 human melanoma cells.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

H-Glu-Trp-OH | L-Glutamyl-L-tryptophan

Quick Database Links

Gene Symbol

VEGFR