Oglemilast

SKU: orb1706883

Description

Oglemilast (GRC 3886) is a potent and orally bioavailable PDE4 inhibitor, with an IC50 of 0.5 nM for PDE4D3. It reduces pulmonary eosinophil and neutrophil infiltration in experimental models, supporting its research application for inflammatory airway diseases like asthma and COPD.

Research Area

Metabolism Research

Key Properties

• CAS Number: 778576-62-8
• MW: 516.3
• Purity: 99.82%
• Formula: C₂₀H₁₃Cl₂F₂N₃O₅S
• SMILES: CS(=O)(=O)Nc1ccc2oc3c(OC(F)F)ccc(C(=O)Nc4c(Cl)cncc4Cl)c3c2c1
• Target: PDE
• Solubility: DMSO:3.6 mg/mL (6.97 mM)

Bioactivity

• Target IC50:
  PDE4D3:0.5 nM
• In Vitro:
  For the PDE 4B1 and PDE 4D3 reporter cell lines, Oglemilast has EC50s of 11.4 nM, 4.4 nM, respectively.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PDE4D3, PDE4D, Oglemilast, GRC-3886, GRC 3886, GRC3886

Compound Identifiers

PubChem CID

11387409