OGG1

SKU: orb1729590

Description

OGG1 is a DNA glycosylase enzyme which takes part in base excision repair. OGG1 protein is the main enzyme accountable for the excision of 7, 8-dihydro-8-oxoguanine (8-oxoG), a mutagenic base byproduct which arises as a result of exposure to reactive oxygen species (ROS). OGG1 shows beta lyase activity that nicks DNA 3'' to the lesion.

Research Area

Epigenetics & Chromatin

Images & Validation

• Tested Applications: SDS-PAGE
• Application Notes:
  For research use only

Key Properties

• Source: Human
• Species/Host: E. coli
• Expression System: Intercellular
• Biological Origin: Recombinant protein expressed as His tage protein in E.coli
• Tag: Histidine
• Molecular Weight: ~40 kDa
• Protein Sequence: SSGLVPRGSHTGSMPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLADQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHFQEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHGFPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKALCILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELGNFFRSLWGPYAGWAQAVLFSADLRQCRHAQEPPAKRRKGSKGPEG
• Purity: ≥95%
• Endotoxins: Not tested
• Conjugation: Unconjugated

Storage & Handling

• Storage: After reconstitution, store at -20°C; Avoid repeated freeze thaw
• Form/Appearance: Lyophilized
• Buffer/Preservatives: No preservative
• Concentration: 1mg/mL
• Expiration Date: 6 months from date of receipt.
• Hazard Information: For Research use only
• Disclaimer: For research use only

Alternative Names

HMMH, HOGG1, MUTM, OGH1