OGG1-IN-08

SKU: orb1299023

Description

OGG1-IN-08 is a potent and selective small molecule inhibitor of 8-oxoguanine DNA glycosylase 1 (OGG1), exhibiting an IC50 of 0.35 µM. This inhibitor is a valuable chemical probe for investigating the role of OGG1 and the base excision repair pathway in oxidative stress-related research, including studies in cellular and animal models of inflammation, cancer, and neurodegeneration.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 350997-39-6
• MW: 261.13
• Purity: 98.00% (May vary between batches)
• Formula: C₉H₆Cl₂N₂OS
• SMILES: NNC(=O)C1=C(Cl)C2=C(Cl)C=CC=C2S1
• Target: Others
• Solubility: DMSO:27.5 mg/mL (105.31 mM)

Bioactivity

• Target IC50:
  OGG1:0.35 µM
• In Vitro:
  OGG1-IN-O8 is selective for OGG1 over Nei-like DNA glycosylase 1 (NEIL1), endonuclease III homolog 1 (NTH1), and formamidopyrimidine DNA glycosylase (Fpg) at 50 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AP site, 8-oxoguanine DNA glycosylase 1 (OGG1), lyase, OGG1, OGG1 IN 08, OGG1IN08, OGG-1-IN-08, OGG1-IN-08, OGG1-IN-O8, inhibit, Inhibitor, glycosylase, FapyGua

Compound Identifiers

PubChem CID

874733