Ogerin

SKU: orb1307935

Description

Ogerin is a selective positive allosteric modulator of GPR68 (pEC50 6.83) that has been shown to inhibit fear memory recall in mouse models. It also exhibits inverse agonist/antagonist activity at the adenosine A2A receptor (Ki 220 nM) and weak antagonist activity at the serotonin 5-HT2B receptor (Ki 736 nM). This profile makes it a useful research tool for studying neuropsychiatric conditions and GPCR signaling in both in vivo and in vitro experiments.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1309198-71-7
• MW: 307.35
• Purity: 99.90% (May vary between batches)
• Formula: C₁₇H₁₇N₅O
• SMILES: Nc1nc(NCc2ccccc2)nc(n1)-c1ccccc1CO
• Target: GPCR,5-HT Receptor,Adenosine Receptor
• Solubility: DMSO:250 mg/mL (813.4 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (16.27 mM)

Bioactivity

• Target IC50:
  5-HT2B receptor:(ki)736 nM|GPR68:(pEC50)6.83 |A2A receptor:(ki)220 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, Ogerin, HEK293, GPR68, fibrotic diseases, G Protein-Coupled Receptor 68, fibroblasts, 5HTReceptor, 5HT Receptor, A2A, A2A receptoor, 5-HT2B receptor, 5-HT2B, AdenosineReceptor, Adenosine Receptor, TGF-β

Compound Identifiers

PubChem CID

56707820