OG-L002

SKU: orb1301098

Description

OG-L002 is a potent and selective LSD1 inhibitor with an IC50 of 20 nM, demonstrating 69-fold and 36-fold selectivity against MAO-A and MAO-B, respectively. It is a valuable chemical probe for studying epigenetic regulation in cancer research and has been utilized in both cellular and animal models of leukemia and solid tumors.

Research Area

Epigenetics & Chromatin, Infectious Disease & Virology, Neuroscience

Key Properties

• CAS Number: 1357302-64-7
• MW: 225.29
• Purity: 97.05%
• Formula: C₁₅H₁₅NO
• SMILES: N[C@H]1C[C@@H]1c1ccc(cc1)-c1cccc(O)c1
• Target: Monoamine Oxidase,Histone Demethylase,HSV
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (4.44 mM);Ethanol:16 mg/mL (71.02 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (244.13 mM)

Bioactivity

• Target IC50:
  LSD1:20 nM
• In Vivo:
  OG-L002 (6 to 40 mg/kg) represses HSV Primary infection in a dose-dependent manner in a mouse model. Moreover, OG-L002 also represses HSV reactivation from latency in a mouse ganglion explant model.
• In Vitro:
  OG-L002 potently inhibits HSV IE gene expression In both HeLa and HFF cells with IC50 of ~10 μM and ~3 μM , respectively OG-L002 treatment 50 μM ) results in the reduced production of progeny virus with no significant toxicity in HeLa or HFF cells. OG-L002 50 μM ) increase the levels of repressive chromatin on viral IE gene promoters. In addition, OG-L002 also represse the expression of h mV IE genes and adenovirus E1A gene.
• Cell Research:
  HeLa or HFF cells are treated wit the indicated concentration of saponin (positive control) or compound OG-L002 for 12 hours. Cytotoxicity is determined using conditions recommended b the manufacturer and expressed as ratios to the cytotoxicity o the DMSO control.(Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

Herpes simplex virus, MAO, MAO-A, MAO-B, MonoamineOxidase, Monoamine Oxidase, monoamine, HistoneDemethylase, Histone Demethylase, HSV, OG L002, OG-L 002, OGL002, OG-L002, OG-L-002, oxidases, LSD1, inhibit, Inhibitor

Compound Identifiers

PubChem CID

56639570