OF-1

SKU: orb1306419

Description

OF-1

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 919973-83-4
• MW: 440.31
• Purity: 98.55%
• Formula: C₁₇H₁₈BrN₃O₄S
• SMILES: COc1cc2n(C)c(=O)n(C)c2cc1NS(=O)(=O)c1ccc(Br)cc1C
• Target: Epigenetic Reader Domain
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.27 mM);DMSO:8.8 mg/mL (19.99 mM)

Bioactivity

• Target IC50:
  BRPF2:500 nM(Kd)|BRPF1B:100 nM(Kd)
• In Vitro:
  As a chemical probe for BRPF bromodomains, OF-1 increases thermal stability in the cellular thermal shift assay of full length BRPF1B at 1 μM and also demonstrates accelerated FRAP recovery at 5 μM in the BRPF2 FRAP assay. In addition, OF-1 shows modest general cytotoxicity.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRPF1B, BRPF2, Inhibitor, inhibit, OF 1, OF1, OF-1, EpigeneticReaderDomain, Epigenetic Reader Domain

Compound Identifiers

PubChem CID

35397514