Oenothein B

SKU: orb1297015

Description

Oenothein B is a potent and selective poly(ADP-ribose) glycohydrolase (PARG) inhibitor. This ellagitannin compound is a valuable research tool for studying DNA repair, inflammation, and cell death pathways, with demonstrated bioactivity in both cellular and animal models of cancer and inflammation.

Research Area

Cell Biology, Infectious Disease & Virology, Protein Biochemistry

Key Properties

• CAS Number: 104987-36-2
• MW: 1569.08
• Purity: 99.94% (May vary between batches)
• Formula: C₆₈H₄₈O₄₄
• SMILES: OC1=C(C(C(O)=C2O)=C(C=C2O)C3=O)C(C(O[C@H]4[C@H](OC(C5=CC(O)=C(O)C(O)=C5)=O)[C@@H](OC(C(C=C6O)=C(C(O)=C6O)OC7=C(O)C(O)=C8C9=C7)=O)[C@H](O)O[C@@H]4CO3)=O)=CC(OC(C(O)=C%10O)=C(C=C%10O)C(O[C@@H]%11[C@@H](OC(C%12=CC(O)=C(O)C(O)=C%12)=O)[C@H](OC(C%13=C8C(O)=C(O)C(O)=C%13)=O)[C@@H](COC9=O)O[C@H]%11O)=O)=C1O
• Target: Antibacterial,Apoptosis,Antifungal,HCV Protease

Bioactivity

• In Vivo:
  In ICR mice, Oenothein B (100-300 mg/kg; p.o.) reduced neuroinflammation in the brain during systemic inflammation.
• In Vitro:
  Oenothein B (15-45 µM; 24 hours) increased intracellular reactive oxygen species (ROS) and upregulated apoptotic triggers (cleavage caspase-3, PARP, cytosolic cytochrome c, Bax). Oenothein B (15-45 µM) demonstrated a dose- and time-dependent inhibition on A549 cells over 12-72 hours, inhibiting their proliferation by inducing apoptosis and arresting cells at the G1 stage.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

poly(ADP-ribose), anti-HCV, antitumor, antioxidant, anti-inflammatory, antifungal, Apoptosis, Bacterial, Oenothein B, macrocyclic, inhibit, ellagitannin, glycohydrolase, Fungal, Hepatitis C virus, HCV, HCV Protease, HCVProtease, Inhibitor

Compound Identifiers

PubChem CID

162989121