Octreotide

SKU: orb1223920

Description

Octreotide is a synthetic long-acting cyclic octapeptide with pharmacologic properties mimicking those of the natural hormone somatostatin. Octreotide is a more potent inhibitor of growth hormone, glucagon, and insulin than somatostatin. Similar to somatostatin, this agent also suppresses the luteinizing hormone response to gonadotropin-releasing hormone, decreases splanchnic blood flow, and inhibits the release of serotonin, gastrin, vasoactive intestinal peptide (VIP), secretin, motilin, pancreatic polypeptide, and thyroid stimulating hormone.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 83150-76-9
• MW: 1019.24
• Purity: >98% (HPLC)
• Formula: C₄₉H₆₆N₁₀O₁₀S₂
• SMILES: C[C@H]([C@H]1C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N[C@H](C(=O)N1)CCCCN)CC2=CNC3=CC=CC=C32)CC4=CC=CC=C4)NC(=O)[C@@H](CC5=CC=CC=C5)N)C(=O)NC(CO)C(C)O)O
• Target: Somatostatin Receptor
• Solubility: DMSO: 10 mM

Bioactivity

• In Vitro:
  Western blot analysis. Cell line: Human hepatoblastoma HepG2 cell line. Concentration: 10 8 mM. Incubation time: 6 hours. Result: Increased the protein expression levels of phosphorylated Akt and GSK3β by 140.8% and 12.2%, respectively and the mRNA level of GS also increased.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Somatostatin Receptor