Octahydrocurcumin

SKU: orb1303380

Description

Octahydrocurcumin is a bioactive small molecule with antioxidant and anti-inflammatory properties, demonstrated to suppress LPS-induced inflammation by inhibiting NF-κB nuclear translocation. It exhibits cytotoxic (IC50 = 19.46 µg/mL) and antimicrobial activities, making it a useful research tool for studying inflammatory pathways and infection models in vitro.

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 36062-07-4
• MW: 376.44
• Purity: 99.65% (May vary between batches)
• Formula: C₂₁H₂₈O₆
• SMILES: COc1cc(CCC(O)CC(O)CCc2ccc(O)c(OC)c2)ccc1O
• Target: NF-κB,ROS,Reactive Oxygen Species,Anti-infection
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.77 mM);Ethanol:10 mg/mL (26.56 mM);DMSO:100 mg/mL (265.65 mM)

Bioactivity

• In Vitro:
  OKT3-induced PBMC proliferation was inhibited by curcumin, isocurcumin, bisdesmethoxy-, diacetyl-, tetrahydro-, hexahydro-, and octahydrocurcumin as well as by vanillin, ferulic acid, and dihydroferulic acid with IC50-values of 2.8, 2.8, 6.4, 1.0, 25, 38, 82, 729, 457, and >1,000 μM, respectively. The investigated substances with the strongest effect on radical scavenging were tetrahydro-, hexahydro-, and octahydrocurcumin with IC50 values of 10.0, 11.7, and 12.3 μM, respectively. IC50-values of dihydroferulic acid, ferulic acid, and curcumin were 19.5, 37, and 40 μM. The substances with the lowest radical scavenging activities were vanillin, isocurcumin, diacetylcurcumin, and bisdesmethoxycurcumin with IC50 values higher than 100 μM each.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NFkB, Octahydrocurcumin, NF-κB, NF-kB, NFκB, inhibit, Hexahydrobisdemethoxycurcumin, Inhibitor, Antiinfection, Anti-infection, Antifection, Reactive Oxygen Species, ReactiveOxygenSpecies, ROS

Compound Identifiers

PubChem CID

11068834