OART

SKU: orb3173285

Description

OART (Oxaliplatin-artesunate) is a ferroptosis inducer that significantly inhibits tumor cell proliferation. It promotes tumor ferroptosis by disrupting the glutathione-mediated ferroptosis defense system and enhancing the iron-dependent Fenton reaction, leading to lipid peroxidation in the cytoplasm and mitochondria. Additionally, OART increases tumor immunogenicity, transforming the tumor environment from immunosuppressive to immunosensitive. It exhibits strong tumor regression effects in tumor-bearing mouse models and can be utilized in cancer immunotherapy research.

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Key Properties

• Target: Ferroptosis,Mitochondrial Metabolism,Dehydrogenase,Glutathione Peroxidase,MMP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Ferroptosis,Mitochondrial Metabolism,Dehydrogenase,Glutathione Peroxidase,MMP