OAC1

SKU: orb1306665

Description

OAC1 is a small molecule activator of the pluripotency transcription factor Oct4. It is used in stem cell research to significantly improve the speed and efficiency of generating induced pluripotent stem cells (iPSCs) in vitro.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 300586-90-7
• MW: 237.26
• Purity: 97.38% (May vary between batches)
• Formula: C₁₄H₁₁N₃O
• SMILES: O=C(Nc1cc2cc[nH]c2cn1)c1ccccc1
• Target: DNA Methyltransferase,OCT
• Solubility: Ethanol:23.7 mg/mL (99.89 mM);DMSO:23.7 mg/mL (99.89 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.43 mM)

Bioactivity

• In Vivo:
  OAC1 appears to enhance reprogramming efficiency by increasing transcription of the Oct4-Nanog-Sox2 triad and Tet1, a gene known to be involved in DNA demethylation. OAC1 does not inhibit the p53-p21 pathway or activate Wnt-β-catenin signaling.OAC1 can be used to enhance the reprogramming of somatic cells to a pluripotent state.1 μM OAC1 enhances the reprogramming efficiency by activating the Oct4 and Nanog promoter-driven luciferase reporter genes. In addition, OAC1 enhanced the reprogramming efficiency and accelerated the reprogramming process of pluripotent stem cells (iPSCs) in mouse embryonic fibroblasts (MEFs) treated with four reprogramming factors (Oct4, Sox2, c-Myc and Klf4).
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• Cell Research:
  The Oct4-luc or Nanog-luc cells are treated with compound OAC1 at 1 μM concentration. Luciferase reporter assays are performed 24 h after OAC1 treatment.(Only for Reference)
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, human IMR90 fibroblast cells, HOXB4, Nanog promoters, Oct3/4, OAC 1, OAC1, OAC-1, inhibit, induced pluripotent stem cells, BAS00287861, BAS-00287861, BAS 00287861, CD34+cells, POU5F1, Slc22a3, reprogramming

Compound Identifiers

PubChem CID

789882