O6-Benzylguanine

SKU: orb1299728

Description

O6-Benzylguanine is a potent and irreversible inactivator of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT). It is widely used in cancer research to sensitize tumor cells to alkylating agents in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Molecular Biology

Key Properties

• CAS Number: 19916-73-5
• MW: 241.25
• Purity: 98.90% (May vary between batches)
• Formula: C₁₂H₁₁N₅O
• SMILES: O(CC1=CC=CC=C1)C2=C3C(=NC(N)=N2)N=CN3
• Target: DNA Alkylation|||Apoptosis|||DNA/RNA Synthesis
• Solubility: DMSO:60 mg/mL (248.7 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.29 mM)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA Synthesis, DNA/RNA Synthesis, DNAAlkylation, DNA Alkylation, DNASynthesis, cyclin, Apoptosis, antineoplastic, analog, cancer, O6 Benzylguanine, O6-alkylguanine-DNA-alkyltransferas, O6Benzylguanine, O-6-Benzylguanine, O6-Benzylguanine, p21, PARP1, inhibit, p53, pancreatic, guanine, Inhibitor, RNASynthesis, RNA Synthesis, transcriptional

Compound Identifiers

PubChem CID

4578