O-phenanthroline

SKU: orb1224293

Description

A selective inhibitor of 26S proteasome subunit Rpn11 with IC50 of 10±2 uM; shows no activity for other DUBs (USP1/USP2/USP4/USP5/USP7/USP8/USP20/UCH37, IC50>50 uM); blocks cellular proteasome function, induces apoptosis in MM cells and overcomes resistance to proteasome inhibitor bortezomib, activates caspase cascade and endoplasmic stress response signaling; reduces progression of tumor growth and prolongs survival in mice MM xenograft model.(In Vitro):o-Phenanthroline (1,10-Phenanthroline, 1mM) inhibits autolysis of sea cucumber body wall.

Key Properties

• CAS Number: 66-71-7
• MW: 180.21
• Purity: >98% (HPLC)
• Formula: C₁₂H₈N₂
• SMILES: C1=CC2=C(C3=C(C=CC=N3)C=C2)N=C1
• Target: Proteasome
• Solubility: In Vitro: DMSO : 100 mg/mL (554.91 mM)

Bioactivity

• In Vitro:
  o-Phenanthroline (1, 10-Phenanthroline, 1 mM) inhibits autolysis of sea cucumber body wall.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

1,10-phenanthroline | Ortho-phenanthroline | OPA

Quick Database Links

Gene Symbol

Proteasome