O-Desethyl Dapagliflozin

SKU: orb1685562

Description

O-Desethyl Dapagliflozin (Empagliflozin-4) is an active metabolite and potent SGLT2 inhibitor with an IC50 of 33 nM. It is a valuable reference compound for pharmacokinetic and metabolic studies in diabetes research, applicable in both in vitro enzymatic assays and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 864070-37-1
• MW: 380.82
• Purity: 98.33% (May vary between batches)
• Formula: C₁₉H₂₁ClO₆
• SMILES: O[C@H]1[C@@H](O[C@H](CO)[C@@H](O)[C@@H]1O)C2=CC(CC3=CC=C(O)C=C3)=C(Cl)C=C2
• Target: SGLT
• Solubility: DMSO:27.5 mg/mL (72.21 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (13.13 mM)

Bioactivity

• Target IC50:
  SGLT2:33 nM

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Empagliflozin-4, O-Desethyl Dapagliflozin, SGLT2

Compound Identifiers

PubChem CID

44580555