O-304

SKU: orb1299883

Description

O-304 is a potent small molecule activator of AMP-activated protein kinase (AMPK) across all its isoforms. It is utilized in metabolic research to study energy homeostasis and has demonstrated efficacy in preclinical models of type 2 diabetes and age-related metabolic decline.

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1261289-04-6
• MW: 380.25
• Purity: 99.84% (May vary between batches)
• Formula: C₁₆H₁₁Cl₂N₃O₂S
• SMILES: Clc1ccc(Cn2sc(NC(=O)c3ccc(Cl)cc3)nc2=O)cc1
• Target: AMPK
• Solubility: DMSO:45 mg/mL (118.34 mM);10% DMSO+90% Corn Oil:2 mg/mL (5.26 mM)

Bioactivity

• In Vivo:
  In vivo, O-304 (100 mg/kg) prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, O304, O-304, O 304, AMPK, AMP-activated protein kinase

Compound Identifiers

PubChem CID

50923806