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NW16

SKU: orb2814563

Description

NW16 is an orally bioavailable STAT3 inhibitor (Kd = 11.0 µM) that exhibits potent anti-proliferative activity in vitro against HCT116, A549, and B16 cancer cells. It induces S-phase arrest, apoptosis, and ROS production while suppressing the PI3K/AKT pathway, and has demonstrated in vivo antitumor efficacy in mouse models.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

MW336.3
FormulaC18H12N2O5
TargetSTAT,Apoptosis,ROS

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

NW16 (orb2814563)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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