NVS-CECR2-1

SKU: orb1693117

Description

NVS-CECR2-1 is a selective small-molecule inhibitor of the CECR2 bromodomain, displacing it from chromatin. This compound exhibits cytotoxic and pro-apoptotic activity, demonstrating antitumor effects in cellular assays and providing a tool for probing CECR2 function in oncology and epigenetics research.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 1992047-61-6
• MW: 495.68
• Purity: 98.68% (May vary between batches)
• Formula: C₂₇H₃₇N₅O₂S
• SMILES: O=S(=O)(C1=NC(=CC(=N1)C2=CC=C3C(C=CN3C4CC(NC(C)(C)C4)(C)C)=C2)NC5CC5)CCC
• Target: CDK,Apoptosis,Epigenetic Reader Domain
• Solubility: DMSO:50 mg/mL (100.87 mM);10% DMSO+90% Corn Oil:2.5 mg/mL (5.04 mM)

Bioactivity

• Target IC50:
  BRD9:2.3 μM|SW48 cells:0.64 μM|BRD7:5.5 μM|BRD4:>37 μM|CECR2:80 nM (Kd)|CECR2:47 nM
• In Vitro:
  The cells were treated with increasing concentrations of NVS-CECR2-1 up to 4 μM and their clonogenic ability was evaluated afer ten days by colony formation assay. NVS-CECR2-1 inhibited the clonogenic ability of SW48 cells in a dose dependent manner and its IC50 value was estimated to be 0.64 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NVSCECR21, NVS-CECR-2-1, NVS-CECR2-1, NVS CECR2 1, Apoptosis, CECR2

Compound Identifiers

PubChem CID

117072550