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NVP-TNKS656

SKU: orb1223313

Description

NVP-TNKS656, also known as TNKS656, is a potent and orally active Tankyrase Inhibitor. With an enthalpy-driven thermodynamic signature of binding, highly favorable physicochemical properties, and high lipophilic efficiency, NVP-TNKS656 is well suited for further in vivo validation studies. Bioactivity of TNKS656: TNKS2 IC50 = 6nM, LiPE = 7.0, HEK298 STF IC50 = 3.5nM, Cmax/ Cellular IC50 = 23,000.

Images & Validation

Key Properties

CAS Number1419949-20-4
MW494.58
Purity>98% (HPLC)
FormulaC27H34N4O5
SMILESCOc1ccc(cc1)C(=O)C1CCN(CC(=O)N(CC2CC2)Cc2nc(=O)c3c(CCOC3)[nH]2)CC1
TargetGamma-secretase
SolubilityDMSO : ≥ 40 mg/mL. 80.88 mM

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

NVPTNKS656 | TNKS656 | TNKS656

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  • NVP-TNKS656 [orb1304373]

    99.59% (May vary between batches)

    1419949-20-4

    494.58

    C27H34N4O5

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 mg, 2 mg, 1 ml x 10 mM (in DMSO)
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Protocol Information

NVP-TNKS656 (orb1223313)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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200 mg
500 mg
2 mg
$ 100.00
5 mg
$ 140.00
10 mg
$ 200.00
25 mg
$ 380.00
50 mg
$ 630.00
100 mg
$ 910.00