NVP-BVU972

SKU: orb1223402

Description

NVP-BVU972, also known as BVN-972, is a selective and potent inhibitor of c-Met with IC50 of 14 nM. BVN-972 displays IC50 values more than 1000 nM in other kinases such as the most closely related kinase recepteur d'origine nantais (RON).

Key Properties

• CAS Number: 1185763-69-2
• MW: 340.38
• Purity: >98% (HPLC)
• Formula: C₂₀H₁₆N₆
• SMILES: Cn1cc(cn1)c1nn2c(Cc3cc4c(cc3)nccc4)cnc2cc1
• Target: PARP
• Solubility: DMSO : ≥ 42 mg/mL. 123.39 mM

Bioactivity

• In Vitro:
  NVP-BVU972 (600 nM-9.6 μM; 72 h) shows good antiproliferative activity to BaF3 cells with MET mutations. NVP-BVU972 (0-10 μM; 2 h) reduces TPR-MET phosphorylation in a dose-dependent manner in BaF3 TPR-MET cells. Cell Proliferation Assay Cell line: BaF3 TPR-MET cells. Concentration: 600 nM-9.6 μM Incubation time: 72 h. Result: Exhibited good antiproliferative effect on BaF3 cells with MET mutations, showed IC50s of 1.2, 3.6, 14.1, 14.6, 31.5, >129 and >129 nM for M1211 L, M1250T, F1200I, V1155 L, L1195V, D1228A and Y1230H mutations, respectively. Showed antiproliferative effect on BaF3 cells containing wild-type (WT) TPR-MET, with an IC50 of 77 nM. Western blot analysis. Cell line: BaF3 TPR-MET cells. Concentration: 0, 0.01, 0.1, 1, 10 μM Incubation time: 2 h. Result: Inhibited phosphorylation of TPR-MET in a dose-dependent manner.
  Read more...

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NVP-BVU972 | NVP-BVU 972 | NVP-BVU-972

Quick Database Links

Gene Symbol

PARP