NVP-BAW2881

SKU: orb1303967

Description

NVP-BAW2881 (BAW2881) is a potent, selective VEGFR tyrosine kinase inhibitor. It has demonstrated efficacy in suppressing both chronic and acute skin inflammation in preclinical models, making it a valuable research tool for studying angiogenesis and inflammatory diseases.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 861875-60-7
• MW: 424.38
• Purity: 98.19%
• Formula: C₂₂H₁₅F₃N₄O₂
• SMILES: Nc1nccc(Oc2ccc3c(cccc3c2)C(=O)Nc2cccc(c2)C(F)(F)F)n1
• Target: Tie-2,Bcr-Abl,Raf,VEGFR
• Solubility: H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:78 mg/mL (183.8 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.71 mM);Ethanol:16 mg/mL (37.7 mM)

Bioactivity

• Target IC50:
  VEGFR3:420 nM|VEGFR1:820 nM|Tie2:650 nM|c-ABL:99 nM|C-Raf1:24 nM|B-Raf (V599E):76 nM|VEGFR2 (human):9 nM|VEGF2 (mouse):165 nM
• In Vivo:
  In vitro experiments demonstrated that NVP-BAW2881 was able to inhibit the proliferation, migration, and tubulogenesis of human lymphatic endothelial cells and umbilical vein endothelial cells.
• In Vitro:
  In vitro experiments demonstrated that NVP-BAW2881 was able to inhibit the proliferation, migration, and tubulogenesis of human lymphatic endothelial cells and umbilical vein endothelial cells.
• Cell Research:
  HUVECs or LECs (1.2×103) were seeded into fibronectin-coated 96-well plates. After 24 hours, the cells were transferred into LEC medium containing 2% fetal bovine serum and incubated for an additional 24 hours. Cells(eight wells/condition) were incubated with medium alone(control), 20 ng/ml VEGF-A, or a combination of 20 ng/ml VEGF-A and 1 nmol/L to 1 mol/L NVP-BAW2881. Proliferation was also assayed in LECs incubated with 500 ng/ml VEGF-C. The dimethyl sulfoxide concentration was adjusted to 0.1% in all wells. After 72 hours, cells were incubated with 5-methylumbelliferylheptanoate for subsequent fluorescent quantification of viable cells, using a SpectraMax Gemini electron microscope. (Only for Reference)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

C-Raf-1, BAW 2881, BAW2881, BAW-2881, c-Abl, B-Raf (V599E), BcrAbl, inhibit, NVP BAW2881, NVP-BAW 2881, NVPBAW2881, NVP-BAW2881, NVP-BAW-2881, Inhibitor, hVEGFR2, Vascular endothelial growth factor receptor, VEGFR

Compound Identifiers

PubChem CID

16004702