NV-5138

SKU: orb1309310

Description

NV-5138 is a leucine-mimetic, orally bioavailable small molecule that acts as a selective intracerebral mTORC1 agonist via Sestrin2 binding. It serves as a research tool for studying mTOR signaling in the context of depression, with applications in both in vitro and in vivo neurological research models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2095886-80-7
• MW: 181.18
• Purity: 99.74% (May vary between batches)
• Formula: C₇H₁₃F₂NO₂
• SMILES: CC(C)(C[C@H](N)C(O)=O)C(F)F
• Target: mTOR
• Solubility: DMSO:10.7 mg/mL (59.06 mM)

Bioactivity

• In Vivo:
  METHODS: Rats were orally administered NV-5138 (40, 80 or 160 mg/kg), and behavioral tests were started 24 hours later, including behavioral despair test (forced swimming test FST) and anxiety test (novelty suppression feeding test NSFT). In FST and NSFT, analyzes were performed 1 or 3 days after dosing. RESULTS NV-5138 significantly reduced immobility time and feeding latency, respectively, at 160 mg/kg but not at 40 or 80 mg/kg. METHODS: To test the duration of the antidepressant effect of NV-5138, rats were orally administered NV-5138 (160 mg/kg) and behavioral tests were started after 3 and 7 days or daily administration for 7 days (starting on day 0 ) of lower doses of NV-5138 (40 or 80 mg/kg, oral) RESULTS NV-5138 significantly reduced immobility time at both 3 and 7 days after FST administration; NV-5138 produced antidepressant effects at repeated low doses of NV-5138 (80mg/kg).

Storage & Handling

• Storage: store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Mammalian target of Rapamycin, NV 5138, NV5138, NV-5138, mTORC1, mTOR, inhibit

Compound Identifiers

PubChem CID

129050791