Nurr1/RXR agonist 1

SKU: orb3174966

Description

Nurr1/RXR dual agonist 1 is a dual activator of Nurr1 (EC50 = 2.6 µM) and RXR, with Ks values of 0.6 and 1.1 µM, respectively. It disrupts the stability of Nurr1 homodimers selectively while stabilizing Nurr1:RXR heterodimers, specifically activating the heterodimer response element DR5. In neuronal cells, Nurr1/RXR dual agonist 1 enhances the expression of neuroprotective Nurr1 target genes without inducing genes associated with off-target effects. This compound is applicable in studies related to neurodegenerative diseases.

Research Area

Metabolism Research

Key Properties

• CAS Number: 2231746-53-3
• MW: 319.35
• Formula: C₁₈H₁₉F₂NO₂
• SMILES: O=C(O)CC1=CC=C(C=C1)N2C(=C(C3=C2CCC(F)(F)C3)C)C
• Target: Retinoid Receptor,NR4A

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Retinoid Receptor,NR4A