Nucleozin

SKU: orb1225256

Description

A small-molecule influenza A nucleoprotein (NP) inhibitor that triggers the aggregation of NP and inhibits its nuclear accumulation; inhibits infection of MDCK cells by viruses influenza A/WSN/33, H3N2 (clinical isolate) and Vietnam/1194/04 (H5N1) with EC50 of 0.069 uM, 0.16 uM and 0.33 uM in PRA, respectively; protects mice challenged with lethal doses of avian influenza A H5N1; also targets cytoplasmic trafficking of viral ribonucleoprotein-Rab11 complexes in influenza A virus infection.Influenza Preclinical.

Key Properties

• CAS Number: 341001-38-5
• MW: 426.853
• Purity: >98% (HPLC)
• Formula: C₂₁H₁₉ClN₄O₄
• SMILES: O=C(N1CCN(C2=CC=C([N+]([O-])=O)C=C2Cl)CC1)C3=C(C)ON=C3C4=CC=CC=C4
• Target: Influenza Virus
• Solubility: DMSO: 28.66 mg/mL (Need ultrasonic)

Bioactivity

• In Vivo:
  Nucleozin protectes mice challenged with lethal doses of avian influenza A H5N1.
• In Vitro:
  Nucleozin inhibits infection of MDCK cells by the viruses influenza A/WSN/33, H3N2 and Vietnam/1194/04 (H5N1) with an EC50 of 0.069 μM, 0.16 μM and 0.33 μM in plaque reduction assay (PRA), respectively, severely suppresses viral growth at 0.1 μM and totally inhibites virus production at 1 μM in multicycle growth assays.
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Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Nucleozin

Quick Database Links

Gene Symbol

Influenza Virus