NU6300

SKU: orb1706895

Description

NU6300 is a covalent, ATP-competitive CDK2 inhibitor (IC50=0.16 µM) that blocks Rb phosphorylation. It also acts as a GSDMD inhibitor by preventing Cys-191 cleavage and palmitoylation, thereby suppressing NLRP3 activation pathways. This dual activity makes it a valuable research tool for studying cell cycle, transcription, and inflammatory diseases like colitis and sepsis in experimental models.

Research Area

Cell Biology, Immunology & Inflammation, Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 2070015-09-5
• MW: 413.49
• Purity: 96.08% (May vary between batches)
• Formula: C₂₀H₂₃N₅O₃S
• SMILES: C=CS(=O)(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3nc[nH]c3n2)cc1
• Target: CDK,NOD

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

118704754