NU6140

SKU: orb1307941

Description

NU6140 is a potent and selective small molecule inhibitor of CDK2-cyclin A, with additional activity against Aurora A and B kinases. It induces apoptosis and demonstrates anti-cancer properties in cellular studies, making it a useful research tool for investigating cell cycle regulation and oncology.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 444723-13-1
• MW: 422.52
• Purity: 98.33% (May vary between batches)
• Formula: C₂₃H₃₀N₆O₂
• SMILES: CCN(CC)C(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3[nH]cnc3n2)cc1
• Target: CDK,Aurora Kinase
• Solubility: DMSO:250 mg/mL (591.69 mM)

Bioactivity

• Target IC50:
  CDK1-CyclinB:6.6 μM|CDK7-CyclinH:3.9 μM|Aurora B:35 nM|Aurora A:67 nM|CDK4-CyclinD:5.5 μM|CDK2-CyclinA:0.41 μM|CDK5-p25:15 μM
• In Vitro:
  NU6140 enhances catalytic activity of capase-9 and capase-3, causes an increase in the sub-G1 apoptotic cell population. NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H (IC50s: 6.6, 5.5, 15 and 3.9 μM, respectively).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NU 6140, NU6140, NU-6140, Inhibitor, inhibit, CDK4/CyclinD, CDK4-Cyclin D, cdk5/p25, cdk7/cyclinH, cdk7-cyclin H, cdk5-p25, CDK, CDK1-Cyclin B, CDK1/CyclinB, cdk2-cyclin A, cdk2/cyclinA, Cyclin dependent kinase, Aurora A, Aurora B, AuroraKinase, Aurora Kinase

Compound Identifiers

PubChem CID

10202471