NU 9056

SKU: orb1704275

Description

NU 9056 is a potent and selective KAT5 histone acetyltransferase inhibitor (IC50 = 2 µM). It disrupts the DNA damage response and reduces protein acetylation in prostate cancer cells, making it a valuable chemical probe for oncology research in both cellular and biochemical assays.

Research Area

Cell Biology, Epigenetics & Chromatin

Key Properties

• CAS Number: 1450644-28-6
• MW: 232.37
• Purity: 97.11% (May vary between batches)
• Formula: C₆H₄N₂S₄
• SMILES: S(Sc1ccns1)c1ccns1
• Target: Apoptosis,Histone Acetyltransferase
• Solubility: DMSO:112.5 mg/mL (484.14 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (14.2 mM)

Bioactivity

• In Vivo:
  In mice, NU 9056 (2 μg/g) inhibits Tip60 and reduces H2A.Z binding at the the +1 nucleosome of Arc and Syp and the -1 nucleosome of Arc. NU 9056 increases the acetylation at the +1 nucleosome of Gria4 and the -1 nucleosome of Fos, Tacstd2, and Gria4.
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• In Vitro:
  NU 9056 shows IC50s of 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively. In LNCaP cells, NU 9056 (17 µM, 24 µM, 36 µM) activates both caspase 3 and caspase 9 in a time- and concentration-dependent manner thereby inducing apoptosis. NU 9056 (2.5 µM, 5 µM, 10 µM, 20 µM, 40 µM) decreases the levels of acetylated histone H4K16, H3K14 and H4K8. NU 9056 causes a reduction of androgen receptor, prostate specific antigen, p53 and p21 protein levels.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NU 9056, NU9056, NU-9056, HistoneAcetyltransferase, Histone Acetyltransferase, histone acetyltransferase

Compound Identifiers

PubChem CID

72201043