NTRC 0066-0

SKU: orb1699793

Description

NTRC 0066-0 is a potent, selective, and orally bioavailable TTK (Threonine Tyrosine Kinase) inhibitor. It blocks substrate phosphorylation, driving chromosome missegregation and aneuploidy, and is utilized in cancer research for studying mitotic mechanisms in both cellular and murine models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1817791-73-3
• MW: 565.71
• Purity: 98.30% (May vary between batches)
• Formula: C₃₃H₃₉N₇O₂
• SMILES: O=C(NC=1C(=CC=CC1CC)CC)C=2C=CN3C4=NC(=NC=C4CCC23)NC5=CC=C(C=C5OC)N6CCN(C)CC6
• Target: Kinesin,Tyrosine Kinases,Others
• Solubility: DMSO:15 mg/mL (26.52 mM)

Bioactivity

• Target IC50:
  TTK:0.9 nM
• In Vitro:
  METHODS: To determine the potential relationship between aneuploidy, CIN, and sensitivity to TTK inhibitors, three cell lines that were relatively sensitive to NTRC 0066-0 and three less sensitive cell lines (colon cancer cell line HCT 116, colorectal adenocarcinoma cell line LoVo, and glioblastoma cell line A-172; cervical cancer cell line DoTc2 4520, osteosarcoma cell line MG-63, and ovarian adenocarcinoma cell line OVCAR-3 were selected in a broad cell panel screen and cell proliferation was measured. RESULTS: Colon cancer cell line HCT 116, colorectal adenocarcinoma cell line LoVo, and glioblastoma cell line A-172 were relatively sensitive to NTRC 0066-0, with IC50 values ​​of 37 nM, 40 nM, and 51 nM, respectively. Cervical cancer cell line DoTc2 4520, osteosarcoma cell line MG-63, and ovarian adenocarcinoma cell line OVCAR-3 were less sensitive, with IC50 values ​​of 117 nM, 135 nM, and 872 nM, respectively.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NTRC 0066 0, NTRC 00660, NTRC 0066-0, NTRC00660, NTRC-00660, NTRC-0066-0, NTRC0066-0, TTK

Compound Identifiers

PubChem CID

122632882