NT113

SKU: orb1699794

Description

NT113 is a brain-penetrant pan-ERBB inhibitor effective against glioblastoma models expressing wild-type EGFR or EGFRvIII. It suppresses ERBB and Akt phosphorylation in vitro and inhibits tumor growth in xenografts with EGFR amplification, supporting its research use in neuro-oncology and kinase signaling studies.

Key Properties

• CAS Number: 1398833-56-1
• MW: 505.97
• Formula: C₂₇H₂₅ClFN₅O₂
• SMILES: C(#CC=1C(NC(/C=C/CN(C)C)=O)=CC2=C(C1)N=CN=C2NC3=CC(Cl)=C(F)C=C3)[C@@H]4[C@@]5([C@]4(COC5)[H])[H]
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

60172363