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NT-0527

SKU: orb3172886

Description

NT-0527 is a selective, orally active, and brain-permeable NLRP3 inflammasome inhibitor that inhibits NLRP3-induced IL-1β in human whole blood (IC50 = 0.79 ± 0.4 µM), and can be used for the study of neuroinflammatory diseases.

Research Area

Immunology & Inflammation, Signal Transduction

Images & Validation

Key Properties

CAS Number2771019-10-2
MW360.77
Purity99.90% (May vary between batches)
FormulaC17H14ClFN4O2
SMILESO=C1C2=CC=C(Cl)C=C2C3(CN1CC(=O)NC4=NC=C(F)C=N4)CC3
TargetNOD,IL Receptor

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information

Available Sizes

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5 mg
$ 80.00
10 mg
$ 100.00
25 mg
$ 150.00
50 mg
$ 220.00
DispatchUsually dispatched within 5-10 working days
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