NT-0249

SKU: orb2664685

Description

NT-0249 is a potent, orally bioavailable NLRP3 inflammasome inhibitor. It demonstrates anti-inflammatory effects in research models, reversing obesity, systemic inflammation, and astrocyte hyperplasia induced by a high-fat diet. This small molecule is a valuable tool for studying NLRP3-driven pathologies in metabolic and neuroinflammatory research.

Research Area

Immunology & Inflammation, Signal Transduction

Key Properties

• CAS Number: 2763617-39-4
• MW: 481.54
• Purity: 98.11% (May vary between batches)
• Formula: C₂₂H₂₈N₅NaO₄S
• SMILES: [N-](C(NS(N(C[C@@H]1CCCO1)C2=CN(C)N=C2)(=O)=O)=O)C3=C4C(=CC5=C3CCC5)CCC4.[Na+]
• Target: NOD-like Receptor (NLR),NOD

Bioactivity

• In Vivo:
  Two structurally distinct NLRP3 inhibitors, NT-0249 and NT-0796, were able to reverse obesity in a mouse model of diet-induced obesity (DIO), and DIO-driven hypothalamic glial fibrillary acidic protein (GFAP) expression could be blocked by administration of NT-0249 or NT-0796.
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NLRP3, NT0249

Compound Identifiers

PubChem CID

171360031