NSC697923

SKU: orb1685641

Description

NSC-697923 is a UBE2N (Ubc13) inhibitor that induces neuroblastoma cell death via p53 nuclear import in wild-type cells or JNK-mediated apoptosis in p53-mutant cells. It also suppresses DNA damage and NF-κB signaling, demonstrating antitumor activity in vitro. This compound is a useful research tool for studying ubiquitination, apoptosis pathways, and neuroblastoma models.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 343351-67-7
• MW: 267.26
• Purity: >98%
• Formula: C₁₁H₉NO₅S
• SMILES: Cc1ccc(cc1)S(=O)(=O)c1ccc(o1)[N+]([O-])=O
• Target: UBC (ubiquitin conjugating enzyme)
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml with warming)

Bioactivity

• In Vivo:
  NSC697923 (5 mg/kg; i.p.; daily for 10 days) suppresses NB tumor growth in SH-SY5Y and NGP xenografts.
• In Vitro:
  NSC697923 (0-5 μM; 24 hours) shows cytotoxic effect on NB cell lines. NSC697923 (3 μM; 2 hours) can also induce apoptosis in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 induces apoptosis in p53 wild-type NB cell lines by promoting p53 nuclear translocation and activation.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ubc13, NSC697923, NSC-697923, NSC 697923, 2-[(4-methylphenyl)sulfonyl]-5-nitrofuran, E3Enzyme, E3 Enzyme, E2Enzyme, E2 Enzyme, E1 Enzyme, E1Enzyme

Compound Identifiers

PubChem CID

394449