NSC632839

SKU: orb1303524

Description

NSC-632839 is a non-selective isopeptidase inhibitor that potently targets deubiquitinating and deSUMOylating enzymes, including USP2, USP7, and SENP2. This compound is a valuable research tool for investigating ubiquitin and SUMO signaling pathways in both cellular and biochemical assays.

Research Area

Cell Biology, Molecular Biology, Protein Biochemistry

Key Properties

• CAS Number: 157654-67-6
• MW: 339.86
• Purity: 99.88% (May vary between batches)
• Formula: C₂₁H₂₂ClNO
• SMILES: Cl.Cc1ccc(\C=C2/CNC\C(=C/c3ccc(C)cc3)C2=O)cc1
• Target: DUB
• Solubility: 0.5% CMC-Na:2 mg/mL (5.88 mM);DMSO:7.5 mg/mL (22.07 mM)

Bioactivity

• Target IC50:
  SENP2:9.8±1.8 μM(EC50)|USP2:45±4 μM(EC50)|USP7:37±1 μM(EC50)
• In Vitro:
  NSC 632839 selectively inhibits ubiquitin isopeptidases, evidenced by its mid-micromolar inhibition of z-LRGG-AMC cleavage in crude lysates, without affecting PLA2 activity at concentrations of 1.2-150 μM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

F 6, F6, F-6, Inhibitor, inhibit, NSC632839, NSC-632839, NSC 632839, DUBs, Deubiquitinase, SENP2, USP2, USP7, Ubiquitin Isopeptidase Inhibitor II

Compound Identifiers

PubChem CID

5351362