NSC632839

SKU: orb1303524

Description

NSC-632839 is a non-selective isopeptidase inhibitor that potently targets deubiquitinating and deSUMOylating enzymes, including USP2, USP7, and SENP2. This compound is a valuable research tool for investigating ubiquitin and SUMO signaling pathways in both cellular and biochemical assays.

Research Area

Cell Biology, Protein Biochemistry

Key Properties

• CAS Number: 157654-67-6
• MW: 339.86
• Purity: >98%
• Formula: C₂₁H₂₁NO · HCl
• SMILES: Cl.Cc1ccc(\C=C2/CNC\C(=C/c3ccc(C)cc3)C2=O)cc1
• Target: DUB (Deubiquitinating enzyme)
• Solubility: Soluble in DMSO (up to 8 mg/ml).

Bioactivity

• Target IC50:
  SENP2:9.8±1.8 μM(EC50)|USP2:45±4 μM(EC50)|USP7:37±1 μM(EC50)
• In Vitro:
  NSC 632839 selectively inhibits ubiquitin isopeptidases, evidenced by its mid-micromolar inhibition of z-LRGG-AMC cleavage in crude lysates, without affecting PLA2 activity at concentrations of 1.2-150 μM.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

F6

Compound Identifiers

PubChem CID

5351362