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NSC45586

SKU: orb1298468

Description

NSC45586 is a selective small molecule inhibitor of the protein phosphatases PHLPP1 and PHLPP2. It is a valuable research tool for studying the Akt and PKC signaling pathways in cancer biology, utilized in both cellular and in vivo experimental models.

Research Area

Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number6300-44-3
MW413.4
Purity99.31% (May vary between batches)
FormulaC20H18N6NaO3+
SMILESCC1=CC(=C(C=C1N)N)N=NC2=CC=C(C=C2)N=NC3=CC(=C(C=C3)O)C(=O)O.[Na+]
TargetSerine Protease,Others,Akt
SolubilityEthanol:Insoluble;H2O:Insoluble;DMSO:82 mg/mL (198.36 mM)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PP2C, PHLPP, PHLPP1, PHLPP2, Inhibitor, NSC 45586, inhibit, NSC-45586, NSC45586, pleckstrin homology domain and leucine-rich repeat protein phosphatase, AKT

Similar Products

  • NSC45586 [orb1217795]

    >98% (HPLC)

    6300-44-3

    413.4

    C20H18N6NaO3+

    500 mg, 25 mg, 50 mg, 100 mg, 5 mg, 1 g, 10 mg, 2 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at [email protected].

Key Properties

No computed properties available.

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NSC45586 (orb1298468)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
10 mg
$ 130.00
25 mg
$ 190.00
50 mg
$ 260.00
100 mg
$ 390.00
200 mg
$ 530.00
DispatchUsually dispatched within 3-5 working days
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