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NSC194598

SKU: orb2278798

Description

NSC194598 is a potent small molecule inhibitor of p53 DNA-binding activity, exhibiting an IC50 of 180 nM in vitro. It is used in research to study radiation and chemotherapy-induced acute toxicity in normal tissues and has been shown to inhibit mutated RET gene transcription in medullary thyroid carcinoma models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number5358-76-9
MW317.38
FormulaC20H19N3O
SMILESO=N=1C(=NC2=CC=CC=3C=4C=CC=CC4C1C23)CN5CCCCC5
TargetOthers,c-RET

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
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Protocol Information