NSC117079

SKU: orb1709009

Description

NSC117079 is a selective small molecule inhibitor of PHLPP1 and PHLPP2 phosphatases. By inhibiting these targets, it promotes AKT activation in neurons, offering protection against apoptotic cell death in models like staurosporine-treated cultures. This tool compound is useful for studying neuroprotection, AKT signaling pathways, and phosphatase function in both in vitro and in vivo research contexts.

Research Area

Metabolism Research

Key Properties

• CAS Number: 500363-63-3
• MW: 473.48
• Purity: 98.11% (May vary between batches)
• Formula: C₂₀H₁₅N₃O₇S₂
• SMILES: O=C1C=2C=CC=CC2C(=O)C3=C(C=C(C(N)=C13)S(=O)(=O)O)NC4=CC=CC(=C4)S(=O)(=O)N
• Target: Phosphatase
• Solubility: DMSO:40 mg/mL (84.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.22 mM)

Bioactivity

• In Vivo:
  The in vivo activity of NSC117079 was evaluated in a mouse model of osteoarthritis induced by destabilization of the medial meniscus (DMM). Twelve-week-old male C57BL/6 mice underwent right knee DMM surgery, followed by a single intra-articular injection of NSC117079 (8 mM, 3 μL; estimated intra-articular concentration ~4 mM) at 7 weeks post-surgery. The results showed that NSC117079 significantly reduced mechanical allodynia, preserved normal activity levels, and slowed articular cartilage degradation .
• In Vitro:
  The in vitro activity of NSC117079 was evaluated in primary rat cortical neurons and astrocytes. Neurons were pretreated with NSC117079 (10–100 μM) for 35 minutes after nutrient deprivation, or co-treated with staurosporine (50–200 nM) for 24 hours; astrocytes were treated for 24 hours after seeding. NSC117079 activated AKT signaling and showed protective effects in neurons, but inhibited signaling and reduced viability in astrocytes .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC117079, NSC-117079, NSC 117079

Compound Identifiers

PubChem CID

272572