NSC 694623

SKU: orb1689467

Description

NSC 694623 is a potent and selective PCAF histone acetyltransferase (HAT) inhibitor with an IC50 of 15.9 µM. It exhibits anti-proliferative effects in various cancer cell lines, making it a useful chemical probe for studying epigenetic mechanisms in oncology research, both in vitro and in vivo.

Research Area

Epigenetics & Chromatin, Neuroscience

Key Properties

• CAS Number: 907957-34-0
• MW: 284.38
• Purity: 99.90% (May vary between batches)
• Formula: C₁₆H₁₆N₂OS
• SMILES: O=C1N(SC=2C1=CC=CN2)C3=CC=C(CCCC)C=C3
• Target: Histone Acetyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (14.07 mM);DMSO:112.5 mg/mL (395.6 mM)

Bioactivity

• Target IC50:
  PCAF:15.9 μM
• In Vitro:
  NSC 694623 exhibits antiproliferative activity against SK-N-SH cells, with an IC50 value of 8.93 μM. Additionally, it inhibits 21% of HCT116 cells at a concentration of 25 μM.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PCAF(p300/CBP-associated factor), histone acetyltransferase, Histone Acetyltransferase, HistoneAcetyltransferase

Compound Identifiers

PubChem CID

393169