NSC 617145

SKU: orb1298314

Description

NSC 617145 is a selective small molecule inhibitor of WRN helicase, specifically blocking its ATPase activity while sparing exonuclease function. This compound is a valuable research tool for studying WRN's role in DNA repair and genome stability in cellular and biochemical assays.

Research Area

Cell Biology, Molecular Biology, Neuroscience

Key Properties

• CAS Number: 203115-63-3
• MW: 400.04
• Purity: 98.31% (May vary between batches)
• Formula: C₁₃H₁₀Cl₄N₂O₄
• SMILES: CC(C)(CN1C(=O)C(Cl)=C(Cl)C1=O)CN1C(=O)C(Cl)=C(Cl)C1=O
• Target: DNA/RNA Synthesis
• Solubility: DMSO:6 mg/mL (15 mM)

Bioactivity

• In Vitro:
  NSC 617145 inhibits growth of HeLa cells via formation of DNA double strand breaks (DSBs) and induction of apoptosis in a WRN helicase-dependent manner. NSC 617145 also acts synergistically with mitomycin C to inhibit growth as well as induce DSBs and chromosomal abnormalities in Fanconia-anemia deficient (FA-D2-/-) cells.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

strand, RNASynthesis, RNA Synthesis, Rad51, WRN helicase, WRN, double, DNASynthesis, DSB, DNA/RNA Synthesis, DNA Synthesis, chromosomal, breaks, abnormalities, ATPase, inhibit, NSC617145, NSC-617145, NSC 617145, NHEJ, Inhibitor, helicase

Compound Identifiers

PubChem CID

357621