NSC 377071

SKU: orb1225483

Description

NSC 377071 (NSC-377071, NSC377071, Cambendazole) is a novel ATG4B antagonist that inhibits autophagy, with no effect on mTOR and PI3K activities; directly inhibits cellular ATG4B activity induced by starvation or rapamycin and suppresses the lipidation of LC3B and autophagosome formation in response to starvation, suppresses Saos-2 osteosarcoma growth in vivo.

Key Properties

• CAS Number: 26097-80-3
• MW: 302.352
• Purity: >98% (HPLC)
• Formula: C₁₄H₁₄N₄O₂S
• SMILES: O=C(OC(C)C)NC1=CC=C2C(N=C(C3=CSC=N3)N2)=C1
• Target: Atg
• Solubility: DMSO: Soluble （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC-377071 | NSC377071 | Cambendazole

Quick Database Links

Gene Symbol

Atg