NSC 370284

SKU: orb1297779

Description

NSC 370284 is a direct STAT3/5 inhibitor that selectively targets and reduces the viability of acute myeloid leukemia (AML) cells exhibiting high TET1 expression. Its efficacy has been demonstrated in both cellular assays and animal models, supporting its use as a research tool for studying oncogenic signaling in AML.

Research Area

Epigenetics & Chromatin, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 116409-29-1
• MW: 387.43
• Purity: 99.74% (May vary between batches)
• Formula: C₂₁H₂₅NO₆
• SMILES: COc1cc(cc(OC)c1OC)C(N1CCCC1)c1cc2OCOc2cc1O
• Target: STAT,DNA Methyltransferase
• Solubility: DMSO:55 mg/mL (141.96 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.16 mM)

Bioactivity

• In Vivo:
  NSC 370284 treatments significantly inhibited MLL-AF9-induced AML in secondary bone marrow transplantation (BMT) recipient mice, and 57% (4 out of 7) of the NSC-370284-treated mice were cured, as the pathological morphologies in peripheral blood (PB), BM, spleen, and liver tissues all turned to normal.
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• In Vitro:
  NSC-370284 exhibited the most significant effects in inhibiting cell viability of all four TET1-high AML cell lines, whereas showing no significant inhibition on viability of NB4/t(15;17) AML cells .The direct binding of STAT3 and STAT5 on the TET1 loci was further validated in MONOMAC-6 cells, and such binding could be disturbed by NSC-370284 treatmen .Analysis suggested a potential direct binding of NSC-370284 to the conserved DNA-binding domain (DBD) of STAT3 or STAT5 .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC 370284, NSC370284, NSC-370284, STAT3/5

Compound Identifiers

PubChem CID

340208