NSC 23925B

SKU: orb3211318

Description

NSC 23925B is a P-glycoprotein (P-gp) inhibitor and the most bioactive isomer of NSC23925, capable of reversing and preventing P-gp-mediated multidrug resistance in cancer cells. It exhibits weak inhibition against most CYP450 enzymes (IC50 > 10 μM) but shows moderate inhibition of CYP2B6 and CYP2D6, with IC50 values of 8.589 μM and 1.407 μM, respectively. NSC 23925B is useful for studying multidrug-resistant cancers.

Key Properties

• CAS Number: 1369591-04-7
• MW: 421.36
• Formula: C₂₂H₂₆Cl₂N₂O₂
• SMILES: O[C@H]([C@@]1([H])CCCCN1)C2=CC(C3=CC=C(C=C3)OC)=NC4=C2C=CC=C4.Cl.Cl
• Target: Cytochromes P450,P-gp

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Cytochromes P450,P-gp