NSC 23766 trihydrochloride

SKU: orb1226871

Description

A specific small molecule inhibitor of Rac GTPase; potently blockes serum or PDGF-induced Rac1 activation and lamellipodia formation without affecting the activity of endogenous Cdc42 or RhoA; inhibits the proliferation, anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.

Key Properties

• CAS Number: 1177865-17-6
• MW: 530.9644
• Purity: >98% (HPLC)
• Formula: C₂₄H₃₈Cl₃N₇
• SMILES: Cl.Cl.Cl.CCN(CC)CCCC(C)NC1=NC(C)=CC(NC2=CC3=C(N)C=C(C)N=C3C=C2)=N1 |c:14,20,26,29,31,t:11,18,23|
• Target: Ras
• Solubility: H2O: ≥ 32 mg/mL; DMSO: 7.6 mg/mL

Bioactivity

• In Vivo:
  NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice.
• In Vitro:
  NSC 23766 (100 μM) treatment effectively inhibits polar body emission in a dose-dependent manner. NSC 23766 (200 μM) increases the percentage of morphologically abnormal spindles of oocytes. In NSC 23766-treated oocytes, the p-MAPK protein expression is significantly decreased. NSC23766 (50 μM) plus 100 ng/mL Jagged1, GDF9 and BMP15, reduces the number of germLine cell cysts and increases the number of primordial follicles. NSC23766 significantly inhibits GTP-Rac1 activity and phosphorylation of Rac1-PAK, ERKs and p38 MAPK in the spinal dorsal horn neurons.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC-23766 trihydrochloride | NSC23766 trihydrochloride

Quick Database Links

Gene Symbol

Ras