NSC 185058

SKU: orb1225128

Description

NSC 185058 (NSC185058, NSC-185058, 2-Pyridinecarbothioamide) is a novel ATG4B antagonist that inhibits autophagy with IC50 of 50 uM, with no effect on mTOR and PI3K activities; directly inhibits cellular ATG4B activity induced by starvation or rapamycin and suppresses the lipidation of LC3B and autophagosome formation in response to starvation, suppresses Saos-2 osteosarcoma growth in vivo; markedly slows tumor growth and provides a significant survival benefit in GBM xenografts combined with radiotherapy.

Key Properties

• CAS Number: 39122-38-8
• MW: 215.274
• Purity: >98% (HPLC)
• Formula: C₁₁H₉N₃S
• SMILES: S=C(C1=NC=CC=C1)NC2=NC=CC=C2
• Target: Atg
• Solubility: DMSO: 30 mg/mL, 139.36 mME; thanol: 2.5 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

NSC185058 | NSC-185058 | 2-Pyridinecarbothioamide

Quick Database Links

Gene Symbol

Atg